Clinical researcher reviewing study notes for Migraine Research Fund

2018 research profile

Nathaniel Schuster, MD

An archive summary of a randomized, double-blind, placebo-controlled clinical study designed to examine inhaled cannabinoid formulations for acute migraine treatment.

Acute treatmentClinical trialPlacebo controlled

Study record

Research profile at a glance

This page preserves the essential study description supplied in the original profile. It does not report current recruitment, study status, results, safety conclusions, or clinical recommendations.

Researcher
Nathaniel Schuster, MD
Institution at award
University of California San Diego Center for Pain Medicine
Program
2018 Impact Award
Study title
Efficacy of inhaled cannabis versus placebo for the acute treatment of migraine: a randomized, double-blind, placebo-controlled trial
Study design
A blinded, randomized comparison of three vaporized cannabinoid formulations—CBD, THC, and combined CBD/THC—with placebo for acute migraine treatment.

Understanding the study

What the design was intended to examine

Controlled clinical trials compare predefined interventions under a structured protocol. Blinding and placebo comparison can help researchers evaluate observed differences while reducing certain forms of bias.

Questions in scope

  • Whether the studied formulations differed from placebo for acute migraine treatment
  • How separate CBD, THC, and combined formulations compared within the trial protocol
  • What safety and tolerability observations arose in the enrolled study population

Important limits

A study title and design summary do not establish benefit, safety, regulatory status, or suitability for an individual. Interpretation requires the full protocol, participant data, statistical analysis, limitations, and any peer-reviewed publication.

How to read this profile

From archive record to informed context

Use this page as a starting point for understanding the research question—not as a substitute for published results or qualified medical guidance.

STEP 01

Identify the question

Note the intervention, comparison group, intended use, and population addressed by the study.

STEP 02

Check the design

Randomization, blinding, and placebo control describe methods, but do not predict the result.

STEP 03

Look for results

Consult complete, current research records and peer-reviewed reporting before drawing conclusions.

STEP 04

Discuss care

Ask a qualified clinician about evidence, risks, interactions, legal considerations, and suitable options.

Frequently asked questions

About this archive profile

Answers distinguish the historical project description from current evidence and individual care.

Does this profile say the intervention was effective?

No. It describes the study question and design only. No efficacy conclusion or numerical result was included in the supplied profile.

Is the study still underway?

The historical source described it that way, but the page did not provide a reliable current status. This archive therefore makes no claim about recruitment, completion, publication, or follow-up.

What does randomized mean?

Participants are assigned to study groups by a defined random process. This can improve comparability between groups and reduce selection bias.

Why use blinding and a placebo?

Blinding can reduce the influence of expectations, while a placebo group provides a structured comparison. The exact protections depend on how the trial was conducted.

Does inclusion in this archive endorse cannabis for migraine?

No. A research profile records a scientific question; it is not an endorsement, prescription, safety assurance, or statement of legal status.

Can this information guide my treatment?

It should not be used on its own for treatment decisions. Discuss migraine symptoms and treatment options with an appropriately qualified clinician.

Where can I explore related research?

Visit the research overview or browse researcher profiles.

Questions about this profile?

Contact Migraine Research Fund for general website and archive enquiries.

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